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Behav Brain Res. 2020 Jan 29:112517. doi: 10.1016/j.bbr.2020.112517. [Epub ahead of print]

Temporal development of neurochemical and cognitive impairments following reserpine administration in rats.

Author information

1
Graduate Program of Developmental and Cellular Biology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil; Graduate Program of Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil. Electronic address: alinegp77@gmail.com.
2
Graduate Program of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
3
Department of Pharmaceutical Sciences, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
4
LABOX, Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
5
Graduate Program of Developmental and Cellular Biology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil; Graduate Program of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
6
Graduate Program of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil; Graduate Program of Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.

Abstract

The systemic administration of low reserpine (RES) doses (0.1 - 1.0 mg/kg) has been proposed as a valuable rat model for the study of non-motor symptoms of Parkinson's disease (PD). Here, we investigated the temporal-dependent effects of RES (1 mg/kg, s.c.) on short-term memory and locomotion, as well as, the levels of dopamine, serotonin and its metabolites in the striatum, hippocampus and prefrontal cortex at 3, 24 or 72 h after RES administration. RES administrations resulted in social and object recognition memory impairment and increased dopamine turnover in the striatum, without changes in the rat spontaneous locomotor activity, 3 h after RES administration. Altogether, these results provide new insights for the use of RES administration as an experimental design for the study of PD non-motor symptoms in rats.

KEYWORDS:

Behavior; Monoamine Levels; Parkinson’s Disease; Pre-motor Symptoms; Reserpine

PMID:
32006562
DOI:
10.1016/j.bbr.2020.112517

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