Format

Send to

Choose Destination
Neurosci Lett. 2020 Jan 28;721:134765. doi: 10.1016/j.neulet.2020.134765. [Epub ahead of print]

NFKF is a synthetic fragment derived from rat hemopressin that protects mice from neurodegeneration.

Author information

1
Proteimax Biotechnology, 05581001, São Paulo, Brazil.
2
Special Laboratory of Pain and Signaling, Butantan Institute, São Paulo, 05503-900, Brazil.
3
Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo, 05508-900, São Paulo, Brazil.
4
Biosciences Institute, São Paulo State University, 11330-900, São Vicente, Brazil.
5
Remer Consultores Ltda., São Paulo, 01411-001, SP, Brazil.
6
Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo, 05508-900, São Paulo, Brazil. Electronic address: eferro@usp.br.

Abstract

Previous studies suggested the pharmacological potential of rat hemopressin (PVNFKFLSH) and its shorter synthetic peptide NFKF, to protect from pilocarpine-induced seizures in mice. Orally administered NFKF was shown to be hundred times more potent than cannabidiol in delaying the first seizure induced by pilocarpine in mice. Here, using an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis we have shown that C57BL/6 J mice orally administrated with NFKF (500 μg/kg) presented better EAE clinical scores and improved locomotor activity compared to saline administrated control mice. NFKF blocked the production of IL-1beta and IL-6, and has high scores binding cannabinoid type 2 receptors. Therefore, NFKF is an exciting new possibility to neurodegenerative diseases therapeutics.

KEYWORDS:

Cannabinoid; EAE; Intracellular peptides; Neurodegenerative diseases

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center