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Indian J Med Microbiol. 2019 Jul-Sep;37(3):433-437. doi: 10.4103/ijmm.IJMM_19_227.

Utility of QuantiFERON®-TB gold In-Tube test compared with tuberculin skin test in diagnosing tuberculosis in Indian children with malnutrition.

Author information

1
Department of Paediatrics, Christian Medical College, Vellore, Tamil Nadu, India.
2
Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
3
Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.

Abstract

This prospective cohort study was conducted to compare the accuracy of QuantiFERON®-TB (QFT) Gold In-Tube test and tuberculin skin test (TST) in diagnosing tuberculosis (TB) in predominantly bacille Calmette-Guerin-vaccinated children with a high incidence of malnutrition. The sensitivity of the QFT versus the TST was 69.6% versus 52.9% for WHO-defined TB, with specificity of 86% versus 78.3%, respectively. The concordance of the TST and QFT was 79% overall (κ = 0.430), 62.5% in those with WHO-defined TB and 85.7% in those without TB. Majority of the QFT+/TST - discordance was seen in children with TB, whereas majority of the TST+/QFT - discordance was seen in those without TB. The TST was more likely to be negative in children with moderate-to-severe malnutrition (P = 0.003) compared to the QFT, which was more likely to be positive in younger children. The significantly better performance of the QFT in malnourished children and those at younger ages supports its use for TB diagnosis in these subpopulations.

KEYWORDS:

Children with malnutrition; QuantiFERON-TB Gold In-Tube test; tuberculin skin test; tuberculosis diagnosis

PMID:
32003347
DOI:
10.4103/ijmm.IJMM_19_227
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