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J Cutan Aesthet Surg. 2019 Oct-Dec;12(4):237-239. doi: 10.4103/JCAS.JCAS_122_19.

Autologous Dermal Filler Derived from Cultured Dermal Fibroblasts and Plasma Gel (Fibrogel): One-year Follow-up of a Case.

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Department of Dermatology, Liv Hospital, Istanbul, Turkey.
Department of Plastic and Reconstructive Surgery, Liv Hospital, Istanbul, Turkey.


In recent years, autologous fibroblast injections or plasma gel filler applications have been used in the treatment of facial contour deformities. In this case report, we describe a new method of autologous filler material derived from cultured dermal fibroblast and plasma gel. The plasma gel, which is the bioskeleton of the filler, is prepared from the patient's plasma, which provides a dense environment for a three-dimensional configuration of dermal fibroblasts. Although the plasma gel provides immediate volume effect, the fibroblasts synthesize extracelluar matrix proteins to promote skin rejuvenation. The filler effect occurs immediately after the first injection and persists 12 months after the third injection, without any complication. Long-term result of the presented case is promising for the concept of autologous filler development.


Autologous filler; dermal filler; fibroblast culture; platelet-rich gel; skin rejuvenation

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