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Intern Med J. 2020 Jan 28. doi: 10.1111/imj.14766. [Epub ahead of print]

Comparison of the Effects of Oral Iron Treatment Every Day and Every Other Day in Female Patients with Iron Deficiency Anemia.

Author information

1
Department of Hematology, Van Yüzüncü Yıl University, Faculty of Medicine, Van, Turkey.
2
Department of Internal Medicine, Van Yüzüncü Yıl University, Faculty of Medicine, Van, Turkey.
3
Department of Internal Medicine, Van Training and Research Hospital, Van, Turkey.
4
Department of Hematology, Van Training and Research Hospital, Van, Turkey.

Abstract

BACKGROUND:

It is known that daily divided doses and high doses of iron increase hepcidin and reduce iron absorption. This study aimed to compare treatments of iron replacement every other day at low doses, once a day and twice a day in terms of their effectiveness and frequencies of side effects.

METHODS:

For a month, Group I received 270 mg ferrous sulfate twice a day (total elemental iron dose: 160 mg / day), Group II received 270 mg ferrous sulfate once a day (total elemental iron dose: 80 mg / day), and Group III received 270 mg ferrous sulfate every other day (total elemental iron dose: 80 mg / every other day). Intragroup and intergroup statistical analyses were carried out.

RESULTS:

Hemoglobin (Hb) increased significantly in all three groups (p: 0.00). The increase in Hb levels was similar among the groups (p: 0.09). Ferritin significantly increased in all three groups after the treatment (p: 0.00). The increase in ferritin in Group I was significantly higher than those in Groups II and III (p<0.05). GIS side effects were also significantly higher in Group I in comparison to the others (p: 0.001).

CONCLUSIONS:

A low-dosage of iron treatment every other day may be used in the place of providing iron once or twice every day with similar effectiveness and lower rates of GIS side effects. This article is protected by copyright. All rights reserved.

KEYWORDS:

Iron deficiency; anemia; iron replacement; treatment interval

PMID:
31994303
DOI:
10.1111/imj.14766

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