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Angiogenesis. 2020 Jan 28. doi: 10.1007/s10456-020-09706-0. [Epub ahead of print]

Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis.

Author information

1
Sanquin Research and Landsteiner Laboratory, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands. c.margadant@sanquin.nl.

Abstract

Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as the hierarchical organization into leader (tip) and follower (stalk) cells via a dynamic interplay with Notch. Recent studies reveal novel molecular mechanisms to fine-tune VEGF/Notch signaling and tip/stalk cell function during sprouting angiogenesis.

KEYWORDS:

Dll4; ERK; Notch; Sprouting angiogenesis; Tip cells; VEGF signaling

PMID:
31993833
DOI:
10.1007/s10456-020-09706-0

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