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Food Sci Nutr. 2019 Dec 5;8(1):332-339. doi: 10.1002/fsn3.1310. eCollection 2020 Jan.

Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts.

Author information

1
College of Food Science Fujian Agriculture and Forestry University Fuzhou China.
2
Mycological Research Center Fujian Agriculture and Forestry University Fuzhou China.
3
School of Animal and Comparative Biomedical Sciences University of Arizona Tucson AZ USA.

Abstract

Agaricus blazei Murill (ABM), a medicinal mushroom, has beneficial effects on various human metabolic diseases. The objective of this research was to evaluate the antioxidant and antidiabetic properties of ABM extracts (ethanol extract and ethyl acetate extract). The antioxidant activities of ABM ethanol extract (EE) and ethyl acetate extract (EA) were analyzed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl radical scavenging assays and the reducing power using K3Fe(CN)6 in vitro. Moreover, the effects of EE and EA on α-glucosidase inhibitory activity and improving glucose uptake by HepG2 cells were investigated in vitro. The EA showed stronger antioxidant activity, as well as inhibition of α-glucosidase, compared to EE. The analysis of glucose uptake by HepG2 cells showed that EA had significant glucose-lowering activity and exhibited no difference compared to metformin. The results suggest that ABM extracts could improve the glucose uptake by HepG2 cells and thereby alleviate postprandial hyperglycemia. This investigation provides a strong rationale for further studies on the application of ABM to control type 2 diabetes.

KEYWORDS:

Agaricus blazei Murill; HepG2 cells; antidiabetic activity; antioxidant activity; α‐glucosidase

Conflict of interest statement

The authors declare that they do not have any conflict of interest.

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