An adolescent case of extensive Behçet`s disease successfully treated with Infliximab

Turk J Pediatr. 2019;61(4):585-588. doi: 10.24953/turkjped.2019.04.016.

Abstract

Isıyel E, Bakkaloğlu S, Oğuz D, Yenicesu İ, Boyunağa Ö, Özdemir Y, Damar Ç, Kandur Y, Akçaboy M, Aslan AT, Şişmanlar T, Hasanoğlan E, Buyan N. An adolescent case of extensive Behçet`s disease successfully treated with Infliximab. Turk J Pediatr 2019; 61: 585-588. Cardiac involvement is an uncommon and life-threatening complication of Behçet`s Disease. We present a 14-year-old boy, admitted to our hospital for recurrent hemoptysis. In his radiologic evaluation, a right ventricular thrombus and pulmonary arterial aneurysm were identified. He was diagnosed with Behçet`s Disease, and then he received prednisone and cyclophosphamide. However, his cardiac thrombus enlargened. After his treatment was replaced with infliximab, the pulmonary aneurysms regressed, and the cardiac thrombus disappeared. In conclusion, infliximab should be considered as a reliable option for vascular Behçet`s Disease resistant to conventional treatment.

Keywords: Behçet`s disease; infliximab; intracardiac thrombus; pulmonary embolism.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Aneurysm / diagnosis
  • Aneurysm / drug therapy*
  • Aneurysm / etiology
  • Antirheumatic Agents / therapeutic use
  • Behcet Syndrome / complications
  • Behcet Syndrome / drug therapy*
  • Computed Tomography Angiography
  • Echocardiography
  • Heart Diseases / diagnosis
  • Heart Diseases / drug therapy*
  • Heart Diseases / etiology
  • Heart Ventricles
  • Humans
  • Infliximab / therapeutic use*
  • Male
  • Pulmonary Artery*
  • Thrombosis / diagnosis
  • Thrombosis / drug therapy*
  • Thrombosis / etiology

Substances

  • Antirheumatic Agents
  • Infliximab