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J Microbiol Biotechnol. 2020 Jan 9. doi: 10.4014/jmb.1912.12014. [Epub ahead of print]

IL-10 expression-inducing gut bacteria alleviate high-fat diet-induced obesity and hyperlipidemia in mice.

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Department of Food and Nutrition, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Department of Food and Nutrition, Eulji University, Seongnam-shi, Gyeonggi-do 13135, Korea.


In the present study, we examined the effects of interleukin (IL)-10 expression-inducing bacteria Bifidobacterium adolescentis HP1, Lactobacillus mucosae HP2, and Weissella cibaria HP3 on high fat diet (HFD)-induced obesity and liver steatosis in mice. Oral gavage of HP1, HP2, and HP3 reduced HFD-induced bodyweight gain and triglycerides and total cholesterol levels in the blood and liver. They also suppressed HFD-induced colitis and fecal δ,γ-Proteobacteria population. Of the tested bacteria, HP2, which most potently inhibited IL-10 expression, suppressed HFD-induced bodyweight gain, liver steatosis, and colitis most potently. These finding suggest that IL-10 expression-inducing gut bacteria can suppress obesity and liver steatosis.


IL-10; colitis; gut bacteria; liver steatosis; obesity

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