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J BUON. 2019 Nov-Dec;24(6):2429-2434.

Long non-coding RNA PCAT1 promotes cell migration and invasion in human laryngeal cancer by sponging miR-210-3p.

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1
Department of Otolaryngology, Affiliated Hospital of Putian University, Putian 351100, China.

Abstract

PURPOSE:

Laryngeal cancer (LC) is one of the most ordinary head and neck cancers worldwide. In this study, the role of long non-coding RNA (lncRNA) PCAT1 in LC was explored.

METHODS:

PCAT1 expression in 50 paired tissue samples from LC patients was monitored by real-time quantitative polymerase chain reaction (RT-qPCR). Afterwards, function assays were conducted to explore how PCAT1 participated in metastasis of LC in vitro and in vivo. Then, bio-information software and luciferase assay were utilized to predict the possible target microRNA (miR) of PCAT1 in LC.

RESULTS:

PCAT1 was obviously upregulated in LC tissues compared with adjacent tissues. Knockdown of PCAT1 inhibited the ability of cell migration and invasion in LC. Moreover, knockdown of PCAT1 inhibited tumor formation in vivo. Furthermore, miR-210-3p was sponged by PCAT1 in LC cells.

CONCLUSION:

PCAT1 was first identified as a novel oncogene in LC and could promote LC cell migration and invasion by sponging miR-210-3p.

PMID:
31983116
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