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FEMS Yeast Res. 2020 Feb 1;20(1). pii: foaa005. doi: 10.1093/femsyr/foaa005.

Transcriptional control of hyphal morphogenesis in Candida albicans.

Author information

1
Masters in Biomedical Science Program, Midwestern University, 19555 N. 59th Ave. Glendale, AZ 85308, USA.
2
Arizona College of Osteopathic Medicine, Midwestern University, 19555 N. 59th Ave. Glendale, AZ 85308, USA.
3
Quantitative and Systems Biology Graduate Program, School of Natural Sciences, University of California, Merced, Merced, CA, 95343, USA.
4
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
5
Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Université Laval, Quebec City, QC, Canada.
6
Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, CA, 95343, USA.
7
Department of Pathology and Population Medicine, College of Veterinary Medicine, Midwestern University, 19555 N. 59th Ave. Glendale, AZ 85308, USA.

Abstract

Candida albicans is a multimorphic commensal organism and opportunistic fungal pathogen in humans. A morphological switch between unicellular budding yeast and multicellular filamentous hyphal growth forms plays a vital role in the virulence of C. albicans, and this transition is regulated in response to a range of environmental cues that are encountered in distinct host niches. Many unique transcription factors contribute to the transcriptional regulatory network that integrates these distinct environmental cues and determines which phenotypic state will be expressed. These hyphal morphogenesis regulators have been extensively investigated, and represent an increasingly important focus of study, due to their central role in controlling a key C. albicans virulence attribute. This review provides a succinct summary of the transcriptional regulatory factors and environmental signals that control hyphal morphogenesis in C. albicans.

KEYWORDS:

C. albicans ; environmental signals; hyphae; morphogenesis; transcription factor(s)

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