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J Med Virol. 2020 Jan 25. doi: 10.1002/jmv.25685. [Epub ahead of print]

Coronavirus infections and immune responses.

Li G1,2, Fan Y3, Lai Y3, Han T3, Li Z2, Zhou P1, Pan P2, Wang W1, Hu D4, Liu X5, Zhang Q1,6, Wu J1,4.

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Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China.
Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
School of Pubic Health, Southern Medical University, Guangzhou, China.


Coronaviruses (CoVs) are by far the largest group of known positive-sense RNA viruses having an extensive range of natural hosts. In the past few decades, newly evolved Coronaviruses have posed a global threat to public health. The immune response is essential to control and eliminate CoV infections, however, maladjusted immune responses may result in immunopathology and impaired pulmonary gas exchange. Gaining a deeper understanding of the interaction between Coronaviruses and the innate immune systems of the hosts may shed light on the development and persistence of inflammation in the lungs and hopefully can reduce the risk of lung inflammation caused by CoVs. In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment.


chemokine; coronavirus; cytokines; inflammation; interferon


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