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Genetics. 1988 Oct;120(2):605-13.

The maintenance of single-locus polymorphism. I. Numerical studies of a viability selection model.

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  • 1Department of Biological Sciences, Stanford University, California 94305.


The ability of viability selection to maintain single-locus polymorphism is investigated with two models in which the population is bombarded with a series of mutations with random fitnesses. In the first model, the population is allowed to reach equilibrium before mutation resumes; in the second the iterations and mutation occur simultaneously. Monte Carlo simulations of these models show that viability selection is easily able to maintain stable 6- or 7-allele polymorphisms and that monomorphisms and diallelic polymorphisms are uncommon. The question of how monomorphisms arise is also discussed.

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