OXA-181-Producing Extraintestinal Pathogenic Escherichia coli Sequence Type 410 Isolated from a Dog in Portugal

Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02298-19. doi: 10.1128/AAC.02298-19. Print 2020 Mar 24.

Abstract

Two multidrug-resistant and carbapenemase-producing Escherichia coli clones of sequence type 410 were isolated from fecal samples of a dog with skin infection on admission to an animal hospital in Portugal and 1 month after discharge. Whole-genome sequencing revealed a 126,409-bp Col156/IncFIA/IncFII multidrug resistance plasmid and a 51,479-bp IncX3 blaOXA-181-containing plasmid. The chromosome and plasmids carried virulence genes characteristic for uropathogenic E. coli, indicating that dogs may carry multidrug-resistant E. coli isolates related to those causing urinary tract infections in humans.

Keywords: Escherichia coli; ExPEC; carbapenemase; companion animals; pets; veterinary.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Proteins / metabolism
  • Cat Diseases / microbiology
  • Cats
  • Dog Diseases / microbiology*
  • Dogs
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / veterinary*
  • Escherichia coli Proteins / genetics*
  • Escherichia coli Proteins / metabolism
  • Extraintestinal Pathogenic Escherichia coli / genetics*
  • Extraintestinal Pathogenic Escherichia coli / isolation & purification*
  • Extraintestinal Pathogenic Escherichia coli / metabolism
  • Extraintestinal Pathogenic Escherichia coli / pathogenicity
  • Feces / microbiology
  • Gastrointestinal Microbiome
  • Genome, Bacterial
  • Phylogeny
  • Plasmids
  • Portugal
  • Skin Diseases, Bacterial / microbiology
  • Skin Diseases, Bacterial / veterinary
  • Urinary Tract Infections / microbiology
  • Urinary Tract Infections / veterinary
  • Virulence Factors / genetics
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Bacterial Proteins
  • Escherichia coli Proteins
  • Virulence Factors
  • beta-Lactamases
  • beta-lactamase OXA-181, E coli
  • carbapenemase