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Euro Surveill. 2020 Jan;25(2). doi: 10.2807/1560-7917.ES.2020.25.2.1900749.

Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20.

Author information

1
Department for Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.
2
Centre for Infectious Disease Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
3
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
4
Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
5
Université Clermont Auvergne, CNRS, Laboratoire Microorganismes: Génome et Environnement, Clermont-Ferrand, France.
6
CHU Clermont-Ferrand, Centre National de Référence des entérovirus et parechovirus - Laboratoire Associé, Laboratoire de Virologie, Clermont-Ferrand, France.
7
Institute of Virology, University of Freiburg, Freiburg, Germany.
8
Department of General Pediatrics, St.-Marien-Hospital, Bonn, Germany.
9
National Reference Center for Poliomyelitis and Enteroviruses, Robert Koch-Institute, Berlin, Germany.
10
Institute of Virology, University of Bonn Medical Center, Bonn, Germany.
11
Institute of Virology, University of Leipzig, Leipzig, Germany.
12
Department of Paediatrics, Aarhus University Hospital, Aarhus, Denmark.
13
Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.
14
Swiss Institute of Bioinformatics, Basel, Switzerland.
15
Biozentrum, University of Basel, Basel, Switzerland.

Abstract

Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 January 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 patients required hospitalisation and five had severe neurologic manifestations. Phylogenetic analysis revealed two clusters in the B3 subclade and subclade A2/D. This circulation of EV-D68 associated with neurological manifestations stresses the importance of surveillance and diagnostics beyond expected peak years.

KEYWORDS:

acute flaccid myelitis; enterovirus D68; novel strains; severe respiratory infection; surveillance

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