Mechanistic insights in recov-ER-phagy: micro-ER-phagy to recover from stress

Autophagy. 2020 Feb;16(2):385-386. doi: 10.1080/15548627.2019.1709767.

Abstract

Physiological and pathological stresses may cause swelling of the endoplasmic reticulum (ER), a biosynthetic organelle in eukaryotic cells. Upon conclusion of the stress, ER size and content return to physiological levels. The translocon component SEC62 decorates the portions of excess ER that must be cleared from cells. Our recent paper highlights the role of endosomal sorting complex required for transport (ESCRT)-III-driven micro-ER-phagy in ER remodeling during cell recovery from ER stress.

Keywords: Autophagosome biogenesis; ER-centric; ER-phagy; ESCRT-III; LC3 lipidation; Recov-ER-phagy; autophagy; endolysosomes; micro-ER-phagy; unfolded protein response (UPR).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy*
  • Endoplasmic Reticulum / metabolism*
  • Endoplasmic Reticulum Stress*
  • Endosomal Sorting Complexes Required for Transport / metabolism
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Models, Biological

Substances

  • Endosomal Sorting Complexes Required for Transport
  • Microtubule-Associated Proteins

Grants and funding

This work was supported by the Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [310030_184827].