A case of Fusarium solani osteomyelitis is reported in a previously healthy adult male who received multiple injuries during an automobile accident. Combined histologic and mycologic data proved it to be a case of hyalohyphomycosis resulting from Fusarium. To the best of the authors' knowledge, this is the first reported case of osteomyelitis resulting from F. solani. A concurrent case of saprophytic wound colonization by the same organism is reported in another patient in the same ward who had sustained similar injuries. Evidence suggests that this represents nosocomial spread from the first case.