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Cell Host Microbe. 2019 Dec 11;26(6):703-705. doi: 10.1016/j.chom.2019.11.010.

HIV Latency: Stochastic across Multiple Scales.

Author information

1
Gladstone|UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, the Netherlands.
2
Gladstone|UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.
3
Gladstone|UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA; Departments of Biochemistry and Biophysics, and Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: leor.weinberger@gladstone.ucsf.edu.

Abstract

Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic transitions to exponential viral expansion require a critical threshold of virus.

PMID:
31951580
DOI:
10.1016/j.chom.2019.11.010
[Indexed for MEDLINE]

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