SnapShot: Splicing Alterations in Cancer

Cell. 2020 Jan 9;180(1):208-208.e1. doi: 10.1016/j.cell.2019.12.011.

Abstract

RNA splicing, the spliceosome-catalyzed process by which pre-messenger RNA (pre-mRNA) is processed to mature mRNA, is altered in a number of ways in cancer. Tumor-specific splicing alterations are created by mutations that disrupt splicing-regulatory elements within genes and impair splicing recognition or by altering the RNA-binding preferences of individual splicing factors. This SnapShot summarizes our current understanding of splicing-factor alterations in cancers. To view this SnapShot, open or download the PDF.

MeSH terms

  • Alternative Splicing / genetics*
  • Humans
  • Mutation
  • Neoplasms / genetics*
  • RNA Precursors / metabolism
  • RNA Splice Sites / genetics*
  • RNA Splicing / genetics
  • RNA Splicing / physiology
  • RNA Splicing Factors / genetics
  • RNA, Messenger / metabolism
  • Spliceosomes / metabolism

Substances

  • RNA Precursors
  • RNA Splice Sites
  • RNA Splicing Factors
  • RNA, Messenger