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Indian J Radiol Imaging. 2019 Oct-Dec;29(4):397-403. doi: 10.4103/ijri.IJRI_385_19. Epub 2019 Dec 31.

Stem cell therapy in critical limb ischemia: Current scenario and future trends.

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Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India.
Department of Radiodiagnosis, BRAIRCH, All India Institute of Medical Sciences, New Delhi, India.


Critical limb ischemia (CLI) represents the most severe manifestation of peripheral arterial disease (PAD). It imposes a huge economic burden and is associated with high short-term mortality and adverse cardiovascular outcomes. Prompt recognition and early revascularization, surgical or endovascular, with the aim of improving the inline bloodflow to the ischemic limb, are currently the standard of care. However, this strategy may not always be feasible or effective; hence, evaluation of newer pharmacological or angiogenic therapies for alleviating the symptoms of this alarming condition is of utmost importance. Cell-based therapies have shown promise in smaller studies; however, large-scale studies, demonstrating definite survival benefits, are entailed to ascertain their role in the management of CLI.


Critical limb ischemia; peripheral arterial disease; stem cell therapy

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