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Taiwan J Ophthalmol. 2019 Dec 13;9(4):288-291. doi: 10.4103/tjo.tjo_107_17. eCollection 2019 Oct-Dec.

Blindness due to leptomeningeal carcinomatosis as an initial manifestation of recurrent acute lymphoblastic leukemia.

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Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan.
Department of Hematology and Oncology, Changhua Christian Hospital, Changhua, Taiwan.


Leptomeningeal carcinomatosis (LC) is an uncommon presentation of acute lymphoblastic leukemia (ALL), and it is a devastating and life-threatening complication. The disease affects all levels of the central nervous system, and most patients present with different multifocal neurological symptoms. This case was a 34-year-old male who had acute bilateral blindness secondary to recurrent ALL with meningeal infiltration. Diagnosis of LC is made based on the clinical symptoms and the test results including cranial and spinal magnetic resonance imaging and cerebrospinal fluid (CSF) survey. The differential diagnosis of meningeal enhancement and early treatment are also important for prognosis. This case had a good visual recovery after treatment.


Acute lymphoblastic leukemia; blindness; leptomeningeal carcinomatosis

Conflict of interest statement

The authors declare that there are no conflicts of interests of this paper.

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