Format

Send to

Choose Destination
J Cancer Res Ther. 2019;15(7):1642-1646. doi: 10.4103/jcrt.JCRT_77_17.

Inhibition of the hypoxia-induced factor-1α and vascular endothelial growth factor expression through ginsenoside Rg3 in human gastric cancer cells.

Author information

1
Department of General Surgery, Xuzhou Central Hospital, Affiliated to Medical College of Southeast University, Xuzhou, China.
2
Department of Breast Surgery, Xuzhou Central Hospital, Affiliated to Medical College of Southeast University, Xuzhou, China.

Abstract

Objective:

The aim of this study is to probe in the inhibitory effects of ginsenoside Rg3 on the expression of hypoxia-induced factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human gastric cancer cells.

Materials and Methods:

Human gastric cancer BGC823 cells were divided into the control group and experiment group, and expression levels of HIF-1α and VEGF were detected by immunocytochemistry and Western blot after cells were cultured under hypoxia for different durations.

Results:

Under hypoxia, expression of HIF-1α and VEGF in human gastric cancer BGC823 cells showed an increasing trend, and that was remarkably lower in experiment group than in the control group after applying Rg3, which was obvious at 12 and 24 h (P < 0.05).

Conclusion:

Rg3 can inhibit expression of HIF-1α and VEGF in human gastric cancer cells and may influence abdominal implantation metastasis of gastric cancer through inhibiting its expression.

KEYWORDS:

Ginsenoside Rg3; human gastric cancer cell; hypoxia-induced factor-1α; vascular endothelial growth factor

PMID:
31939450
DOI:
10.4103/jcrt.JCRT_77_17
Free full text

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd
Loading ...
Support Center