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J Am Mosq Control Assoc. 1988 Jun;4(2):152-8.

Microplate assay analysis of reduced fenitrothion susceptibility in Haitian Anopheles albimanus.

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  • 1Division of Parasitic Diseases, Centers for Disease Control, Atlanta, GA 30333.


Reduced fenitrothion susceptibility in Haitian Anopheles albimanus is documented using time/mortality measurements from otherwise standard World Health Organization (WHO) bioassays. Survival beyond a time threshold in bioassays is shown to be highly correlated with elevated non-specific esterase levels. A shift in resistance incidence from less than 20 to over 60% in a six-month period is documented using both the bioassay and microassay procedures, showing the potential of microplate assay methods in early detection of resistance. Conventional 24-hour reading of WHO bioassay data failed to detect resistance until the level reached 60%. Resistance appeared to be focal, with an increase in intensity coinciding with a fenitrothion spray cycle for malaria control.

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