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J Immunol Res. 2019 Dec 20;2019:3758576. doi: 10.1155/2019/3758576. eCollection 2019.

The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies.

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Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Research and Development Division, Amino Up Co., Ltd., 004-0839 Sapporo, Japan.


Mushrooms have been used for various health conditions for many years by traditional medicines practiced in different regions of the world although the exact effects of mushroom extracts on the immune system are not fully understood. AHCC® is a standardized extract of cultured shiitake or Lentinula edodes mycelia (ECLM) which contains a mixture of nutrients including oligosaccharides, amino acids, and minerals obtained through liquid culture. AHCC® is reported to modulate the numbers and functions of immune cells including natural killer (NK) and T cells which play important roles in host defense, suggesting the possible implication of its supplementation in defending the host against infections and malignancies via modulating the immune system. Here, we review in vivo and in vitro effects of AHCC® on NK and T cells of humans and animals in health and disease, providing a platform for the better understanding of immune-mediated mechanisms and clinical implications of AHCC®.

Conflict of interest statement

Insoo Kang received unrestricted research funding from Amino Up Co., Ltd., Sapporo, Japan, the manufacturer of AHCC® that was discussed in this work, and is a consultant of Amino Up Co., Ltd. Takahiro Maeda, Hiroshi Nishioka, and Fujii Hajime are employees of Amino Up Co., Ltd.

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