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J Oncol. 2019 Dec 20;2019:5956867. doi: 10.1155/2019/5956867. eCollection 2019.

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance.

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Department of Biological Sciences and Institute of Life Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea.


Radiotherapy is widely used for the treatment of cancer patients, but tumor radioresistance presents serious therapy challenges. Tumor radioresistance is closely related to high levels of mTOR signaling in tumor tissues. Therefore, targeting the mTOR pathway might be a strategy to promote solid tumor sensitivity to ionizing radiation. Radioresistance is associated with enhanced antioxidant mechanisms in cancer cells. Therefore, examination of the relationship between mTOR signaling and antioxidant mechanism-linked radioresistance is required for effective radiotherapy. In particular, the effect of mTOR signaling on antioxidant glutathione induction by the Keap1-NRF2-xCT pathway is described in this review. This review is expected to assist in the identification of therapeutic adjuvants to increase the efficacy of radiotherapy.

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