Clinical and histopathological correlative studies carried out in 100 cases of leprosy with macular lesions revealed an overall parity in 47% of the cases. Disparity was observed in TT, BT, BB, BL and IL series but not in LL series. The variable tissue response in the disease spectrum due to the variability of CMI is responsible for the disparity in various types of leprosy, irrespective of the type of lesions, whether macular or elevated.