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Aging (Albany NY). 2020 Jan 11;12(1):902-911. doi: 10.18632/aging.102663. Epub 2020 Jan 11.

SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer.

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Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China.
Institute of Translational Medicine, Zhejiang University, School of Medicine, Hangzhou 310029, Zhejiang, China.
Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, Zhejiang, China.
Departmant of Galactophore Surgery, The Second Affiliated Hospital of Guangzhou University of traditional Chinese Medicine, Guangdong 510120, China.
Departmant of Plastic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ZhejiangChina.


SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulated in breast cancer cells and that SAG overexpression is associated with significant poorer survival in breast cancer, especially the luminal A subtype. We also detected highly correlated co-overexpression of SAG and COPB2 in breast cancers. Subsequent in vitro experiments demonstrated that SAG and COPB2 act cooperatively to stimulate breast cancer cell proliferation, migration and invasion. Our findings suggest that levels of SAG and COPB2 expression may be useful prognostic indicators in breast cancers and that SAG may be involved in COPB2-related signaling during breast cancer development.


COPB2; SAG; breast cancer; prognosis; proliferation

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