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Drug Test Anal. 2020 Jan 10. doi: 10.1002/dta.2763. [Epub ahead of print]

Studies of athlete biological passport biomarkers and clinical parameters in male and female users of anabolic androgenic steroids and other doping agents.

Author information

1
Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
2
Clinical Pharmacology, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden.
3
Department of Medicine, Karolinska Institutet and St Görans Hospital, Stockholm, Sweden.
4
Anti-Doping Laboratory, Clinical Pharmacology, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden.
5
Ambulance Medical Service in Stockholm [Ambulanssjukvården i Storstockholm AB], Academic EMS, Stockholm, Sweden.
6
Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Södersjukhuset, Stockholm, Sweden.

Abstract

The use of anabolic androgenic steroids (AAS) and other performance enhancing substances can change over time, so there is a need to constantly update what substances are used and can be detected. Six women and 30 men anabolic androgenic steroid users were recruited who filled out an anonymous questionnaire about their use of performance enhancing substances during the past year. Sampling took place on a single occasion and included blood and urine collection. Our aim was to identify which doping agents can be detected in men and women self-reporting AAS use. The first choice of substances differed between men (testosterone) and women (oxandrolone). The use of growth hormones was reported among men (10%) and women (50%). Growth hormone releasing factors/secretagogs were reported by about ~ 20% in both genders. Nandrolone was the most frequently detected anabolic androgenic steroid even in those who did not report use in the past year. Of the current male testosterone users, 82% exhibited testosterone/epitestosterone (T/E) ratios of > 4. Men with current testosterone use displayed 4-fold and 6-fold higher median T/E, respectively, when compared with recent and previous testosterone users (P = 0.0001). Dermal testosterone use in women (n = 2) was not associated with a T/E ratio of > 4, but with supra-physiological total serum testosterone concentrations. Changes in gonadotropins and hematological parameters were associated with the time of the last anabolic androgenic steroid intake in men, whereas in women these biomarkers were within the normal range. This highlights gender specific differences and indicates the need for additional biomarkers in female athletes.

KEYWORDS:

anabolic androgenic steroids; athlete biological passport; doping tests; testosterone; urinary steroid profile

PMID:
31925932
DOI:
10.1002/dta.2763

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