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Commun Biol. 2019 May 7;2(1):169. doi: 10.1038/s42003-019-0392-8.

Wuchereria bancrofti filaria activates human dendritic cells and polarizes T helper 1 and regulatory T cells via toll-like receptor 4.

Author information

1
Department of Zoology (Centre for Advanced Studies), Visva-Bharati University, Santiniketan, 731235, India.
2
Institut National de la Santé et de la Recherche Médicale; Centre de Recherche des Cordeliers, Equipe-Immunopathologie et immuno-intervention thérapeutique, Sorbonne Universités, F-75006, Paris, France.
3
Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, 713 340, India.
4
Institut National de la Santé et de la Recherche Médicale; Centre de Recherche des Cordeliers, Equipe-Immunopathologie et immuno-intervention thérapeutique, Sorbonne Universités, F-75006, Paris, France. jagadeesh.bayry@crc.jussieu.fr.
5
Université Paris Descartes, Sorbonne Paris Cité, F-75006, Paris, France. jagadeesh.bayry@crc.jussieu.fr.

Abstract

Interaction between innate immune cells and parasite plays a key role in the immunopathogenesis of lymphatic filariasis. Despite being professional antigen presenting cells critical for the pathogen recognition, processing and presenting the antigens for mounting T cell responses, the dendritic cell response and its role in initiating CD4+ T cell response to filaria, in particular Wuchereria bancrofti, the most prevalent microfilaria is still not clear. Herein, we demonstrate that a 70 kDa phosphorylcholine-binding W. bancrofti sheath antigen induces human dendritic cell maturation and secretion of several pro-inflammatory cytokines. Further, microfilarial sheath antigen-stimulated dendritic cells drive predominantly Th1 and regulatory T cell responses while Th17 and Th2 responses are marginal. Mechanistically, sheath antigen-induced dendritic cell maturation, and Th1 and regulatory T cell responses are mediated via toll-like receptor 4 signaling. Our data suggest that W. bancrofti sheath antigen exploits dendritic cells to mediate distinct CD4+ T cell responses and immunopathogenesis of lymphatic filariasis.

PMID:
31924989
DOI:
10.1038/s42003-019-0392-8

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