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Hum Genet. 1988 Nov;80(3):311-4.

Non-random chromosomal aberrations in a complex leukaemic clone of a Bloom's syndrome patient.

Author information

1
Gattegno Research Institute for Human Reproduction and Fetal Development, Hasharon Hospital, Golda Medical Center, Tel Aviv University Medical School, Petah-Tiqva, Israel.

Abstract

Bloom's syndrome is one of the congenital disorders known to have increased frequency of acute leukaemia. The complex cytogenetic findings in the leukaemic cells of a 39-year-old male with Bloom's syndrome are described. These included a translocation t(7;17), missing 7q and 17p, a reciprocal translocation t(4;22); del 3q, del 8q22, del 20q, missing 12 and missing Y. In the same patient a missing Y had been noted 10 years previously in 15% of his peripheral blood lymphocytes.

PMID:
3192221
DOI:
10.1007/bf01790108
[Indexed for MEDLINE]

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