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Alzheimers Dement (N Y). 2019 Nov 19;5:789-796. doi: 10.1016/j.trci.2019.09.017. eCollection 2019.

Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide.

Author information

1
Department of Neuroscience, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA.
2
University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, Bordeaux, France.
3
Department of Neurology, University Hospital of Bordeaux, Bordeaux, France.
4
Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU, Munich, Germany.
5
German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.
6
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
7
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
8
Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia.
9
Centre for Clinical Brain Sciences, UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Little France, Edinburgh.
10
Department of Neurology, G03.232, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.

Abstract

The research into vascular contributions to cognitive impairment and dementia (VCID) aims to understand the importance of cerebrovascular biology in cognitive decline. Prevention and treatment of VCID is poised to have major impact on dementia-related disease burden and is thus a critical emerging objective in dementia research. This article presents VCID consortia focused on multidisciplinary approaches to identify key pathologic targets and develop diagnostic tools with the goal of bridging the divide between basic research and clinical trials. Members of these multi-institute, multidisciplinary consortia provide a prospective on the history and emerging science of VCID and how VCID consortia can address some of the more complex questions in VCID and drive the field forward. These consortia, and others like them, are uniquely suited to tackle some of the most difficult obstacles in translating research to the clinic.

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