Send to

Choose Destination
Front Cell Infect Microbiol. 2019 Dec 12;9:425. doi: 10.3389/fcimb.2019.00425. eCollection 2019.

The Complex Interplay of Parasites, Their Hosts, and Circadian Clocks.

Author information

Laboratory of Molecular Chronobiology, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Laboratory of Infectious Diseases and Immunity, Department of Medicine, Research Institute of the McGill University Health Center, McGill University, Montreal, QC, Canada.


Parasites have evolved various mechanisms to favor infection of their hosts and enhance the success of the infection. In this respect, time-of-day effects were found during the course of parasitic infections, which can be caused or controlled by circadian rhythms in the physiology of their vertebrate hosts. These include circadian clock-controlled rhythms in metabolism and in immune responses. Conversely, parasites can also modulate their hosts' behavioral and cellular rhythms. Lastly, parasites themselves were in some cases shown to possess their own circadian clock mechanisms, which can influence their capacity to infect their hosts. A better knowledge of the circadian regulation of host-parasite interactions will help in designing new preventive and therapeutic strategies for parasitic diseases.


behavior; circadian clock; circadian rhythms; host; immune response; infection; parasite

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center