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FEBS Lett. 1988 Nov 21;240(1-2):163-6.

Stereospecific bioactions of 5-hydroxyeicosatetraenoate.

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1
Department of Medicine, Wake Forest University Medical Center, Winston-Salem, NC 27103.

Abstract

5(S)-Hydroxyicosatetraenoate stimulates human polymorphonuclear neutrophils (PMNs) to raise their cytosolic calcium. It also potentiates the cells' degranulation responses to platelet-activating factor and diacylglycerols. We synthesized 5(R)-hydroxyicosatetraenoate and found it to be 20-100-fold weaker than the natural isomer in these assays. Thus, the arachidonic acid metabolite activates PMNs by a stereospecific possibly receptor-mediated mechanism.

PMID:
3191990
[Indexed for MEDLINE]
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