Stressed-Out T Cells Fragment the Mind

Evan A Bordt; Staci D Bilbo

doi:10.1016/j.it.2019.12.008

Stressed-Out T Cells Fragment the Mind

Trends Immunol. 2020 Feb;41(2):94-97. doi: 10.1016/j.it.2019.12.008. Epub 2020 Jan 6.

Authors

Evan A Bordt¹, Staci D Bilbo²

Affiliations

¹ Pediatrics and Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
² Pediatrics and Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Psychology and Neuroscience, and Department of Neurobiology, Duke University, Durham, NC 27708, USA. Electronic address: staci.bilbo@duke.edu.

Abstract

The immune system is increasingly recognized to play an integral role in regulating stress responses. In a recent article in Cell, Fan et al. demonstrate a novel mechanism through which stress drives mitochondrial fragmentation-induced xanthine accumulation in mouse CD4⁺ T cells, subsequently acting on oligodendrocytes to induce anxiety-like behaviors.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

ATP Citrate (pro-S)-Lyase*
Acetylation
Adenosine Triphosphate
Animals
Histones*
Humans
Macrophages
Mice
Multienzyme Complexes
Oxo-Acid-Lyases
T-Lymphocytes
Toll-Like Receptors

Substances

Histones
Multienzyme Complexes
Toll-Like Receptors
Adenosine Triphosphate
ATP Citrate (pro-S)-Lyase
Oxo-Acid-Lyases
citrate (pro-3S)-lyase

Abstract

Publication types

MeSH terms

Substances

Grants and funding