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Int Ophthalmol. 2020 Jan 8. doi: 10.1007/s10792-019-01254-x. [Epub ahead of print]

Ocular manifestations in celiac disease: an overview.

Author information

1
Department of Gastroenterology and Hepatology, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 45100, Ioannina, Greece.
2
Department of Ophthalmology, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, Ioannina, Greece.
3
Department of Gastroenterology and Hepatology, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 45100, Ioannina, Greece. dchristodoulou@gmail.com.

Abstract

PURPOSE:

To review and highlight the ocular manifestations associated with celiac disease (CD) and presentation of their pathogenetic mechanisms.

METHODS:

A thorough review of the literature was performed using PubMed to identify articles about serrated polyposis syndrome. The search was performed using the search string: ("celiac disease" OR "coeliac disease") AND ("ocular manifestations" OR "eye" OR "orbitopathy" OR "uveitis" OR "neuro-ophthalmic manifestations"). Only articles in English were reviewed.

RESULTS:

Several ocular symptoms and disorders have been associated with CD and are a result of defective intestinal absorption and immunological mechanisms. These include nyctalopia, dry eye, cataract, thyroid-associated orbitopathy, uveitis, central retinal vein occlusion and neuro-ophthalmic manifestations. In addition, CD-related ocular disease may represent the first manifestation of CD.

CONCLUSION:

CD may hold accountable for the development of ocular diseases of obscure etiology.

KEYWORDS:

Celiac disease; Dry eye; Extraintestinal manifestations; Eye; Uveitis

PMID:
31916055
DOI:
10.1007/s10792-019-01254-x

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