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Curr Pharm Des. 2020 Jan 7. doi: 10.2174/1381612826666200107144810. [Epub ahead of print]

Emerging role of Mitophagy in inflammatory diseases: Cellular and Molecular Episodes.

Author information

1
School of Life Sciences, BS Abdur Rahman Crescent Institute of Science & Technology, Chennai. India.
2
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh. Saudi Arabia.

Abstract

Mitochondria are the crucial regulators for major source of ATP for different cellular events. Due to damage episodes, mitochondria have been established for plethora of an alarming signals of stress that leads to cellular deterioration and thereby causing programmed cell death. Defects in mitochondria plays a key role in arbitrating pathophysiological machinery with recent evince delineating a constructive role in mitophagy mediated mitochondrial injury. Mitophagy have been known for eradication of damaged mitochondria via autophagy process. Mitophagy has been investigated as an evolutionarily conserved mechanism for mitochondrial quality control and homeostasis. Impaired mitophagy has been critically linked with pathogenesis of inflammatory diseases. Nevertheless, the exact mechanism is not quite revealed, and it is still debatable. The purpose of this review was to enquire the possible role of mitophagy and its associated mechanism in inflammation mediated diseases at both cellular and molecular level.

KEYWORDS:

Energy Homeostasis; Inflammasomes ; Inflammation; Mitochondria; Mitophagy; Oxidative Stress

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