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Curr Pharm Des. 2020 Jan 7. doi: 10.2174/1381612826666200107143619. [Epub ahead of print]

Role of dietary antioxidants in neurodegenerative diseases: Where are we standing?

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Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul. Turkey.
Department of Pharmacy, Abdul Wali Khan University Mardan 23200. Pakistan.
King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589. Saudi Arabia.


This review presents the potential effects of dietary antioxidants on neurodegenerative diseases. The relationship of autoimmunity and antioxidants, as well as their preventive effect on neurodegenerative diseases are evaluated. The driven factors of neurodegeneration and the potential effects of natural antioxidants are summarized for Alzheimer's disease, Parkinson's disease, multiple sclerosis, spongiform encephalopathy, Huntington's disease, and amyotrophic lateral sclerosis (ALS). The effect of oxidative stress on neurodegenerative diseases and regulative effect of antioxidants on oxidative balance is discussed. This review provides beneficial information for the possible cure of neurodegenerative diseases with dietary intake of antioxidants.


Antioxidants; Dietary Components; Immune System; Neurodegenerative Diseases

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