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Curr Pharm Des. 2020 Jan 7. doi: 10.2174/1381612826666200108113002. [Epub ahead of print]

Type 1 Diabetes and Physical Exercise: Moving (forward) as an Adjuvant Therapy.

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Cardiovascular Diabetology Research Group, Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz. Austria.
Institute of Cellular Medicine, Newcastle University, Newcastle. United Kingdom.
Physiology Division, Otto Loewi Research Center, Medical University of Graz, Graz. Austria.
Exercise Physiology, Training & Training Therapy Research Group, Institute of Sports Science, University of Graz, Graz. Austria.


Type 1 diabetes is characterised by an autoimmune β-cell destruction resulting in endogenous insulin deficiency potentially leading to micro- and macrovascular complications. Besides an exogenous insulin therapy and continuous glucose monitoring, physical exercise is recommended in adults with type 1 diabetes to improve overall health. The close relationship of physical exercise, inflammation, muscle contraction, and macronutrient intake has never been discussed in detail in relation to type 1 diabetes. The aim of this narrative review was to detail the role of physical exercise in improving clinical outcomes, physiological responses to exercise and different nutrition and therapy strategies around exercise. Physical exercise has several positive effects on glucose uptake and systemic inflammation in adults with type 1 diabetes. A new approach via personalized therapy adaptations must be applied to target beneficial effects on complications as well as on body weight management. In combination with pre-defined macronutrient intake around exercise, adults with type 1 diabetes can expect similar physiological responses to physical exercise as seen in their healthy counterparts. This review highlights interesting findings from recent studies related to exercise and type 1 diabetes. However, there is limited research available accompanied by a proper number of participants in the cohort of type 1 diabetes. Especially for this group of patients, increased understanding of the impact of physical exercise can improve its effectiveness as an adjuvant therapy to move (forward).


GLUT-4; Inflammation; Insulin Therapy; Physical Exercise; Type 1 Diabetes

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