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Chem Res Toxicol. 2020 Jan 21;33(1):7-9. doi: 10.1021/acs.chemrestox.9b00499. Epub 2020 Jan 7.

Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium.

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Certara UK Limited , Simcyp Division, Level 2-Acero, 1 Concourse Way , Sheffield , S1 2BJ , United Kingdom.
Research Programme on Biomedical Informatics (GRIB), IMIM (Hospital del Mar Medical Research Institute) , Pompeu Fabra University (UPF) , Dr. Aiguader 88 , 08003 Barcelona , Spain.
Drug Metabolism Pharmacokinetics and Bioanalysis , AbbVie Deutschland GmbH & Co. KG , D-67008 Ludwigshafen , Germany.
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine , University of Liverpool , Liverpool L69 3GE , United Kingdom.
Clinical Pharmacology, ADME, and AI, Clinical Pharmacology and Safety Sciences, Biopharmaceuticals R&D , AstraZeneca , Cambridge CB2 0SL , United Kingdom.
Faculty of Medicine, Institute of Computational Biomedicine , Heidelberg University , 69120 Heidelberg , Germany.


Omics data have been increasingly generated with limited demonstrated value in drug safety assessment. The TransQST consortium was launched to use omics and other data in mechanistic-based quantitative systems toxicology (QST) models to evaluate their potential use in species translation.

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