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Endokrynol Pol. 2020;71(1):66-72. doi: 10.5603/EP.a2019.0066. Epub 2020 Jan 7.

Association of single nucleotide polymorphism (rs741301) of the ELMO1 gene with diabetic kidney disease in Polish patients with type 2 diabetes: a pilot study.

Author information

1
Department of Internal Medicine, Diabetology, and Nephrology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland. hanna.kwiendacz@gmail.com.
2
Department of Internal Medicine, Diabetology, and Nephrology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
3
Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
4
Department of Internal Medicine and Nephrodiabetology, Medical University of Łódź, Łódź, Poland.
5
Department of Clinical Genetics, Medical University of Łodź, Łódź, Poland.

Abstract

INTRODUCTION:

Multifactorial pathogenesis of diabetic kidney disease (DKD) consists of a combination of metabolic, environmental, and genetic factors. A genome-wide association study has shown that ELMO1 is a candidate gene for DKD occurrence and progression. The aim of this study was to assess the association of a single nucleotide polymorphism (rs741301) of the ELMO1 gene with DKD in Polish patients with type 2 diabetes (T2DM).

MATERIAL AND METHODS:

This was a case/control study of 272 T2DM patients with or without DKD. Patients were divided into groups depending on DKD definition according to the American Diabetes Association (ADA) and the National Kidney Foundation (NKF). The association of the rs741301 polymorphism with DKD was assessed in the whole study group as well as in the subgroups stratified according to the presence of DKD.

RESULTS:

There was no association between rs741301 polymorphisms and the presence of DKD in relation to the ADA definition (p = 0.6) or the NKF definition (p = 0.5) of DKD and with estimated glomelural filtration rate (eGFR) value reflecting the stage of the chronic kidney disease (p = 0.8).

CONCLUSIONS:

Even though the results of this study are negative, there is still a great need for larger studies assessing the genetic susceptibility to DKD to identify patients who are particularly prone to this complication.

KEYWORDS:

ELMO1 gene; SNP; diabetes mellitus type 2; diabetic kidney disease; rs741301

PMID:
31909452
DOI:
10.5603/EP.a2019.0066
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