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Eur J Transl Myol. 2019 Nov 12;29(4):8520. doi: 10.4081/ejtm.2019.8520. eCollection 2019 Oct 29.

Exercise preserves muscle mass and force in a prostate cancer mouse model.

Author information

1
School of Nursing, The University of Texas Health at San Antonio, San Antonio, TX, USA.
2
Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, The University of Texas Health at San Antonio, San Antonio, TX, USA.
3
Barshop Institute for Longevity and Aging Studies, The University of Texas Health at San Antonio, San Antonio, TX, USA.
4
Department of Urology, School of Medicine, The University of Texas Health at San Antonio, San Antonio, TX, USA.
5
School of Medicine, The University of Texas Health at San Antonio, San Antonio, TX, USA.
6
The Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA.

Abstract

The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04). Myostatin was significantly lower in the exercise group compared to controls (p=0.01). Exercise mice maintained forelimb grip force while control mice had a significaint decrease (p=0.01). No significant difference was observed in pre-post all limb grip strength. Further, forelimb and all limb grip strength was negatively associated with tumor mass (p<0.01).

KEYWORDS:

cachexia; muscle strength; physical activity; sarcopenia

Conflict of interest statement

Conflict of interest: The authors have no conflicts to disclose. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

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