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Nat Neurosci. 2020 Jan 6. doi: 10.1038/s41593-019-0569-y. [Epub ahead of print]

Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.

Author information

1
Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
2
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
3
Department of Neurobiology and Anatomy, The University of Utah School of Medicine, Salt Lake City, Utah, USA.
4
Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, UK. jbriggs@mrc-lmb.cam.ac.uk.

Abstract

Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.

PMID:
31907439
DOI:
10.1038/s41593-019-0569-y

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