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Biomolecules. 2019 Dec 30;10(1). pii: E59. doi: 10.3390/biom10010059.

Neuroprotective Effects of Quercetin in Alzheimer's Disease.

Author information

1
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
2
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
3
Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China.
4
Department of Pharmacognosy, Faculty of Pharmacy Gazi University, 06330 Etiler/Ankara, Turkey.

Abstract

Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer's disease and its potential as a lead compound in clinical applications.

KEYWORDS:

Alzheimer’s disease; clinical directions; mechanistic insights; polyphenols; quercetin

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