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Arch Toxicol. 1988;61(6):504-5.

Tumour induction in mice following exposure to aristolochic acid.

Author information

1
Department of Toxicology and Experimental Pathology Dr. Madaus GmbH & Co., Köln, Federal Republic of Germany.

Abstract

After treatment for 3 weeks with aristolochic acid (AA) in daily doses of 5.0 mg/kg mice were kept under observation for approximately 1 year. During this period papillomatous changes occurred in the forestomach. At a later stage, squamous cell carcinomas were observed in all the animals. In one case, an adenocarcinoma was found in the glandular stomach. In addition, malignant lymphomas were found, as well as adenomas of the kidneys, carcinomas of the lungs, and haemangiomas of the uteri.

PMID:
3190449
DOI:
10.1007/bf00293699
[Indexed for MEDLINE]

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