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Med Sci (Paris). 2019 Dec;35(12):1114-1120. doi: 10.1051/medsci/2019208. Epub 2020 Jan 6.

[Mechanism of action and adverse effects of monoclonal antibodies].

[Article in French]

Author information

1
Service de Pharmacologie médicale, CHRU de Tours ; EA 7501, GICC, équipe PATCH, Université de Tours, 37000 Tours, France - LabEx MabImprove,.
2
Service de Pharmacologie, CHU Caen ; EA4650, Normandie Université, Caen, 14000, France.

Abstract

Monoclonal antibodies are therapeutic monoclonal Ig that act by highly specific binding to their target antigen and by interacting with the immune system. Their side effects are mainly related to their mechanism of action. The most frequent adverse effects are infusion reactions. Post-marketing surveillance is essential for identifying adverse reactions and improving knowledge of their mechanism of action.

PMID:
31903925
DOI:
10.1051/medsci/2019208

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