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Med Sci (Paris). 2019 Dec;35(12):1098-1105. doi: 10.1051/medsci/2019218. Epub 2020 Jan 6.

[The hinge region of therapeutic antibodies: major importance of a short sequence].

[Article in French; Abstract available in French from the publisher]

Author information

1
Université de Tours, EA7501 GICC (Groupe Innovation et Ciblage Cellulaire), équipe FRAME (Fc Récepteurs, Anticorps et MicroEnvironnement), 37032 Tours, France.
2
Université de Tours, EA7501 GICC (Groupe Innovation et Ciblage Cellulaire), équipe FRAME (Fc Récepteurs, Anticorps et MicroEnvironnement), 37032 Tours, France - Service d'immunologie, CHRU de Tours, 37044 Tours, France.

Abstract

in English, French

The hinge region is a short sequence of the heavy chains (H) of antibodies linking the Fab (Fragment antigen binding) region to the Fc (Fragment crystallisable) region. The functional properties of the four IgG subclasses partly result from the sequence differences of their hinge regions as some amino acids of the lower hinge region are located within or in the close vicinity of the C1q and FcγR binding sites on the IgG H chains. In addition, the hinge is susceptible to proteolytic cleavage by many proteases present in tumor and/or inflammatory microenvironment capable of affecting functional responses. Thus, an optimal format of the hinge region remains a major challenge for the development of new therapeutic antibodies.

PMID:
31903923
DOI:
10.1051/medsci/2019218

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