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Med Sci (Paris). 2019 Dec;35(12):1034-1042. doi: 10.1051/medsci/2019227. Epub 2020 Jan 6.

[Antibody-drug conjugates in oncology. Recent success of an ancient concept].

[Article in French; Abstract available in French from the publisher]

Author information

Institut de Recherche Pierre Fabre, Centre d'Immunologie Pierre Fabre, 5 Avenue Napoléon III, 74160 Saint-Julien-en-Genevois, France.
Cancer Research Center of Lyon (CRCL), Inserm 1052/CNRS, 69000 Lyon, France - Université de Lyon, 69000 Lyon, France - Hospices Civils de Lyon, 69000 Lyon, France.
GICC EA7501, Université de Tours, équipe IMT, 31 avenue Monge, 37200 Tours, France.


in English, French

An Antibody-Drug Conjugate (armed antibody) is a vectorized chemotherapy that results from the grafting of a cytotoxic agent on a monoclonal antibody thanks to a judiciously designed spacer arm. ADCs have made considerable progress in 10 years. In 2009, only gemtuzumab ozogamicin (Mylotarg®) was used clinically. In 2019, 4 other ADCs have been approved and more than 80 others are in active clinical trials. The first part of this review will focus on Food and Drug Administration-approved Antibody-Drug Conjugates, their limitations as well as their associated toxicity and resistance mechanisms.


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