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Oman J Ophthalmol. 2019 Oct 11;12(3):181-185. doi: 10.4103/ojo.OJO_39_2018. eCollection 2019 Sep-Dec.

Long term effect of panretinal photocoagulation on retinal nerve fiber layer parameters in patients with proliferative diabetic retinopathy.

Author information

1
Department of Community Ophthalmology, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India.
2
Department of Ophthalmology, University of Otawa, Canada.
3
Glaucoma Unit, Fortis Hospital, Gurugram, Haryana, India.
4
Retina Unit, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India.
5
Department of Biostatics, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India.
6
Glaucoma Unit, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India.
7
Retina Lab, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India.
8
Department of Ophthalmology, Command Hospital (Central Command), Lucknow, Uttar Pradesh, India.

Abstract

PURPOSE:

This study aimed to evaluate the long-term effect of panretinal photocoagulation (PRP) on the retinal nerve fiber layer (RNFL) in patients with proliferative diabetic retinopathy (PDR).

METHODS:

This was a prospective longitudinal cohort study examining 42 eyes of 42 patients with PDR undergoing PRP. Peripapillary RNFL thickness (RNFLT) was measured using spectral-domain optical coherence tomography at baseline, 1 year, and 3 years following PRP.

RESULTS:

The mean "average RNFLT" was 89.88 ± 14.26 μm at baseline, 85.75 ± 11.36 μm at 1-year follow-up, and 83.33 ± 11.96 μm at 3-year follow-up. There was a statistically significant difference in the average RNFL thickness at baseline and 1 year and 3 years after PRP. At 1-year follow-up, superior, inferior, and nasal RNFL measurements reduced significantly from baseline (P < 0.01). The reduction in RNFL remained statistically significant for superior and inferior quadrants 3 years after PRP.

CONCLUSION:

PRP causes a reduction in RNFL thickness until 3 years after the procedure. Caution should be exercised while interpreting peripapillary RNFL thickness scans in patients who have undergone PRP for diabetic retinopathy.

KEYWORDS:

Optical coherence tomogram; panretinal photocoagulation; proliferative diabetic retinopathy

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