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J Urol. 2020 Jan 3:101097JU0000000000000714. doi: 10.1097/JU.0000000000000714. [Epub ahead of print]

Cardiovascular Risk in Men with Prostate Cancer: Insights from the RADICAL PC Study.

Author information

1
The Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton.
2
Université Laval, Quebec City.
3
McMaster University, Hamilton.
4
Université de Montréal, Montréal.
5
Kingston General Hospital and Queen's University, Kingston.
6
Jewish General Hospital and McGill University, Montréal.
7
Sunnybrook Health Sciences Centre, University of Toronto, Toronto.
8
Niagara Health, St. Catharines.
9
Western University, London.
10
University of Ottawa and the Ottawa Hospital, Ottawa.
11
McGill University Health Centre, McGill University, Montréal.
12
Grand River Hospital, Kitchener.
13
Princess Margaret Cancer Centre and University of Toronto, Toronto.
14
University of British Columbia and Vancouver General Hospital, Vancouver.
15
Institut du cancer de Montréal and Université de Montréal, Montréal.
16
Women's College Hospital and University of Toronto, Toronto.

Abstract

PURPOSE:

To describe the cardiovascular risk profile in a representative cohort of prostate cancer patients treated with or without androgen deprivation therapy (ADT).

MATERIALS AND METHODS:

We prospectively characterized in detail 2492 consecutive men (mean age 68 years) with prostate cancer (newly diagnosed or with a plan to prescribe ADT for the first time) from 16 Canadian sites. Cardiovascular risk was estimated by calculating Framingham risk scores.

RESULTS:

Most (92%) had new prostate cancer (intermediate-risk in 41%; high-risk in 50%). The highest level of education achieved was primary school in 12%. Most (58%) were current or former smokers; 22% had known cardiovascular disease; 16% diabetes; 45% hypertension; 31% body-mass index ≥30kg/m2; 24% had low levels of physical activity; the mean handgrip strength was 37.3kg; 69% had a Framingham risk score consistent with high cardiovascular risk. Participants in whom ADT was planned had higher Framingham risk scores than those not intending to receive ADT; this risk was abolished after adjustment for confounders.

CONCLUSIONS:

Two-thirds of men with prostate cancer is at high cardiovascular risk. There is a positive association between a plan to use ADT and baseline cardiovascular risk factors; however, this association is explained by confounding factors.

KEYWORDS:

cardiovascular; prostate cancer; risk factors

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