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Asian J Transfus Sci. 2019 Jul-Dec;13(2):140-141. doi: 10.4103/ajts.AJTS_28_18. Epub 2019 Dec 3.

An unusual report of anti-N antibody presenting as ABO discrepancy in an old female patient in Palestine.

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Department of Medical Technology, Faculty of Allied Health Sciences, Arab American University, Jenin, Palestine.
Department of Biology and Biochemistry, Faculty of Science, Birzeit University, Birzeit, Palestine.


The MNS is a highly complex immune blood group system which is almost equal to Rh in size and complexity. Anti-N antibody is naturally occurring in general, cold reactive IgM or IgG saline agglutinin and relatively rare when compared with anti-M. The immune type anti-N is seldom encountered. Anti-N antibody is not clinically significant unless it reacts at 37°C. Clinically significant anti-N antibody is reactive at 37°C or in the anti-human globulin phase, which may cause delayed hemolytic transfusion reactions or hemolytic disease of newborn. Here, we report a rare case presented as blood group discrepancy of a naturally occurring anti-N that reacts at 37°C.


Anti-N antibody; MNS blood group system; Palestine

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